Dramatic response with capecitabine after cranial radiation to the brain parenchymal and leptomeningeal metastases from lung cancer

PAYDAŞ S., Bicakci K., Yavuz S.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, cilt.20, sa.1, ss.96-99, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ejim.2008.04.015
  • Dergi Adı: EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-99
  • Anahtar Kelimeler: Capecitabine, Central nervous system metastasis, Blood brain barrier, Radiation, Lung cancer, BREAST-CANCER, THYMIDINE PHOSPHORYLASE, ORAL CAPECITABINE, 5-FLUOROURACIL, IRRADIATION, XENOGRAFTS, PATIENT
  • Çukurova Üniversitesi Adresli: Evet

Özet

It is known that the prognosis of Non Small Cell Lung Cancer with brain metastasis are very poor with a median survival of only a few months. Although some chemotherapeutic agents penetrate the blood brain barrier generally chemotherapy results are bad but efficiency may be better after radiotherapy. For this reason brain metastatic disease requires some efforts to improve the response rate. Here we reported a case with lung cancer metastatic to the brain and we discussed the good response to capecitabine after cranial radiotherapy (C). (C) 2008 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.