High-altitude pulmonary hypertension: Effects of captopril on pulmonary and systemic arterial pressures

Niazova Z., Batyraliev T., Aikimbaev K., Kudaiberdieva G., Akgul F., Soodanbekova Y., ...Daha Fazla

JOURNAL OF HUMAN HYPERTENSION, cilt.10, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 1996
  • Dergi Adı: JOURNAL OF HUMAN HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Çukurova Üniversitesi Adresli: Hayır

Özet

The purpose of investigation was the assessment of the effect of captopril on both systemic (P-a) and pulmonary arterial pressures (P-PA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44 +/- 6.8 years) with HAPH and mild-to-moderate systemic arterial hypertension were included in the study, All the patients underwent right heart catheterization with measurements of systolic P-PA (P-PA,P-syst), mean P-PA (<(P)over bar (PA)>) and diastolic P-PA (P-PA,P-diast). After a 4 week placebo phase, patients with P-PA,P-syst > 25 mm Hg, <(P)over bar (PA)> > 15 mm Hg and systemic diastolic blood pressure (P-a,P-diast) > 100 mm Hg received captopril (50 - 75 mg at 08.00) for a period of 12 weeks, The statistical evaluation of the results were made using the Student's t-test, It was found that captopril significantly decreases P-PA and P-a.