This study aimed to evaluate the perception of surgical teams (doctors) towards surgical site infections (SSIs). A cross-sectional study was carried out in a tertiary care hospital in Pakistan. The questionnaire was completed by 85 surgical team doctors (n = 110) (response rate >= 77%). The respondent perception of SSIs was found significant. Patient hospitalization, care of the patient in the ward, intrinsic and extrinsic factors, assessment of malnutrition, a therapy protocol, inappropriate parameters, criteria of KUNIN, pathological examination, the total length of stay, and rational antibiotics prophylaxis (95% CIp < 0.05) are considered responsible variables for the incidence of SSIs. The obesity and the factors related to the ventilation of operating room (95% CIp < 0.05) are counted insignificant for SSI. The internal consistency for the questionnaire's scale and each factor subscale was good fit (overall = 0.8, each,alpha >= 0.07). Surgeons' perspective has shown that the associated risk factors and treatment outcomes of surgical patients may have a direct association with the incidence of SSIs.