Relationship between IL28B gene rs8099917 polymorphism and SVR in Turkish patients with hepatitis C virus genotype 1


AKKIZ H. , Akgollu E., Bekar A., Yildirim S., Sandikci M., Ulger Y., ...Daha Fazla

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, cilt.39, ss.711-717, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 39 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.clinre.2015.02.008
  • Dergi Adı: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
  • Sayfa Sayıları: ss.711-717

Özet

Background and objective: The hepatitis C virus (HCV) which infects 3% of the world's population is a global challenge. Recently, genome-wide association studies (GWAS) have identified that the IL28B gene rs8099917 polymorphism was associated with the response to the pegylated-interferon alpha/ribavirin (PegIFN alpha/RBV) combination therapy in patients infected with HCV genotype 1. IL28B gene rs8099917 polymorphism should be determined before beginning treatment of HCV-infected patients to predict an individual's response. The aims of this study were to analyze the correlation between IL28B gene rs8099917 (T/G) polymorphism and PegIFN alpha/RBV therapy outcome in the Turkish population.