Microbiota alteration and modulation in Alzheimer's disease by gerobiotics: The gut-health axis for a good mind

AĞAGÜNDÜZ D., Kocaadam-Bozkurt B., Bozkurt O., Sharma H., Esposito R., ÖZOĞUL F., ...Daha Fazla

BIOMEDICINE & PHARMACOTHERAPY, cilt.153, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 153
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.biopha.2022.113430
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Gerobiotics, Probiotics, Alzheimer's disease, Gut-brain axis, Nutrition, INTERNATIONAL SCIENTIFIC ASSOCIATION, CONSENSUS STATEMENT, BRAIN AXIS, PROBIOTICS, BIFIDOBACTERIA, IMPAIRMENT, PREBIOTICS, MEMORY, SCOPE, DIET
  • Çukurova Üniversitesi Adresli: Evet

Özet

The role of the gut microbiota in human health is one of the most important research topics. There is a strong relationship between the microbiota-gut-brain axis and cognitive functions. Since Alzheimer's disease (AD) is a disease characterized by cognitive impairment, the influence of the gut microbiota in the development and treatment of the disease attracts considerable attention. Gerobiotics is a new concept that includes probiotics or derived postbiotics involved in delaying the aging process. Increasing evidence in the literature suggests that gerobiotics has important roles in the pathogenesis and progression of AD, and even in its treatment, through various mechanisms of action. Several researchers have established the linkage between ingestion of gerobiotics and improved gut dysbiosis and cognitive functions, nevertheless the dose and duration of treatment differ based on strain. Furthermore, oxidative-inflammatory pathways are mainly involved in the neuroprotective effects caused by gerobiotics. This review provides the effects of gerobiotics on microbiota alteration and modulation in AD.