TRAIL Death Receptor-4, Decoy Receptor-1 and Decoy Receptor-2 Expression on CD8(+) T Cells Correlate with the Disease Severity in Patients with Rheumatoid Arthritis


Bisgin A., Terzioglu E., Aydin C., Yoldas B., YAZISIZ V., BALCI N., ...Daha Fazla

BMC MUSCULOSKELETAL DISORDERS, cilt.11, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1186/1471-2474-11-192
  • Dergi Adı: BMC MUSCULOSKELETAL DISORDERS

Özet

Background: Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disorder. Although the pathogenesis of disease is unclear, it is well known that T cells play a major role in both development and perpetuation of RA through activating macrophages and B cells. Since the lack of TNF-Related Apoptosis Inducing Ligand (TRAIL) expression resulted in defective thymocyte apoptosis leading to an autoimmune disease, we explored evidence for alterations in TRAIL/TRAIL receptor expression on peripheral T lymphocytes in the molecular mechanism of RA development.