Pharyngocutaneous fistula (PCF) is not uncommon after laryngeal surgery. Because it leads to prolonged hospitalization and increased patient morbidity, it is important to predict the formation of fistula. We studied the wound amylase concentrations of 87 consecutive laryngectomized patients. The PCF rate was 11.5% in this series. The amylase levels in patients with PCF begin to elevate significantly on the third, fourth, and fifth postoperative days. Our data indicate that increase in the wound amylase levels seems to be a significant predictor of PCF, and this should alert the surgeon for the presence of fistula.