Detection of SARS-CoV-2 Antibodies in Matched Pregnant Women and Newborn Blood

Haytoğlu Z., Haytaoğlu E., Gülderen Özlü F., Yapıcıoğlu Yıldızdaş H., Kibar F., Çetiner S., ...More

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, vol.1, no.1, pp.1-10, 2023 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 1 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1055/s-0043-1768200
  • Journal Name: JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database
  • Page Numbers: pp.1-10
  • Çukurova University Affiliated: Yes

Abstract

Objective The factors affecting the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from mother to newborn and the duration of seropositivity rates in these infants have not yet been clearly demonstrated. The objectives of this study were (1) to assess the levels of SARS-CoV-2 spike–specific immunoglobulin G (IgG) in women infected in the pregnancy period and newborns born to these women and (2) to search the transplacental transfer ratio of spike-specific IgG.

Methods Seventy pregnant women with symptomatic SARS-CoV-2 infection and their newborns were prospectively followed. Anti–SARS-CoV-2 immunoassay was used for the detection of the in vitro quantitative determination of total antibodies to the SARS-CoV-2 spike protein.