10. Ulusal ve 1. Uluslararası Veteriner Patoloji Kongresi, Burdur, Türkiye, 27 - 31 Ekim 2020, ss.2
A case of vaginal xanthoma in a 3-year-old Holstein cow is described macroscopically, microscopically and immunohistochemically. A pink-colored mass surgically excised from the vagina was hard, nodular and 328 g in weight. Macroscopically, the cross section of the 17x15x8.5 cm vaginal mass showed whitish lobular structures divided by thin septums. Histopathologically, the mass was consisted of lobular areas surrounded by a stroma and composed of numerous foamy macrophages, abundant lipid material and rarely giant cells. Immunohistochemically, the mass was positive for vimentin, proliferating cell nuclear antigen (PCNA) and CD 68, but negative for smooth muscle actin (SMA), glial fibrillary acidic protein (GFAP) and S100 protein. To the authors’ knowledge, this is the first report of vaginal xanthoma in a cow.