The immunohistochemical analysis of vascular endothelial growth factors A and C and microvessel density in gingival tissues of systemic sclerosis patients: their possible effects on gingival inflammation


Ozcelik O. , HAYTAÇ M. C. , ERGİN M. , ANTMEN B., SEYDAOĞLU G.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, cilt.105, ss.481-485, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 105 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.tripleo.2007.07.021
  • Dergi Adı: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
  • Sayfa Sayıları: ss.481-485

Özet

Objective. In systemic sclerosis (SSC), certain abnormalities can occur in fibroblasts, endothelial cells, and immune system cells. Severe pathological changes such as visceral fibrosis and obliteration of the lumen of arteries may develop due to functional alterations of these cells. Because the vascular abnormality is a central mechanism of sclerosis, the aim of this study was to further investigate the impaired vascularity in the gingival tissues of SSC patients by means of immunohistochemistry using vascular endothelial growth factor A ( VEGF-A), VEGF-C, and CD34 staining.