The immunohistochemical analysis of vascular endothelial growth factors A and C and microvessel density in gingival tissues of systemic sclerosis patients: their possible effects on gingival inflammation

Ozcelik, ONUR; HAYTAÇ, MEHMET; ERGİN, MELEK; ANTMEN, Bulent; SEYDAOĞLU, GÜLŞAH

doi:10.1016/j.tripleo.2007.07.021

The immunohistochemical analysis of vascular endothelial growth factors A and C and microvessel density in gingival tissues of systemic sclerosis patients: their possible effects on gingival inflammation

Ozcelik O., HAYTAÇ M. C., ERGİN M., ANTMEN B., SEYDAOĞLU G.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, cilt.105, sa.4, ss.481-485, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 105 Sayı: 4
Basım Tarihi: 2008
Doi Numarası: 10.1016/j.tripleo.2007.07.021
Dergi Adı: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.481-485
Çukurova Üniversitesi Adresli: Evet

Özet

Objective. In systemic sclerosis (SSC), certain abnormalities can occur in fibroblasts, endothelial cells, and immune system cells. Severe pathological changes such as visceral fibrosis and obliteration of the lumen of arteries may develop due to functional alterations of these cells. Because the vascular abnormality is a central mechanism of sclerosis, the aim of this study was to further investigate the impaired vascularity in the gingival tissues of SSC patients by means of immunohistochemistry using vascular endothelial growth factor A ( VEGF-A), VEGF-C, and CD34 staining.