PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade

KAYASELCUK F., ZORLUDEMIR S., GUMURDULU D., ZEREN H., Erman T.

JOURNAL OF NEURO-ONCOLOGY, cilt.57, sa.2, ss.115-121, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1023/a:1015739130208
  • Dergi Adı: JOURNAL OF NEURO-ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.115-121
  • Anahtar Kelimeler: central nervous system tumors, proliferative activity, grade, Ki-67, PCNA, CELL NUCLEAR ANTIGEN, BROMODEOXYURIDINE LABELING INDEX, MONOCLONAL-ANTIBODY KI-67, HUMAN-BRAIN TUMORS, PROGNOSTIC IMPLICATIONS, PROLIFERATIVE ACTIVITY, EXPRESSION, ASTROCYTOMAS, NEOPLASMS, CYCLE
  • Çukurova Üniversitesi Adresli: Evet

Özet

Determination of proteins in the control of proliferation in normal cells helps a better understanding of cellular transformation and proliferation mechanisms. Measurement of proliferative activity is important in determining the tumor grade, recurrence span and malignancy. Proliferating cell nuclear antigen (PCNA) and Ki-67 are two of the nuclear markers used to demonstrate the proliferative phase of the cell cycle.