PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade

KAYASELCUK, F; ZORLUDEMIR, SUZAN; GUMURDULU, DERYA; ZEREN, H; Erman, TAHSİN

doi:10.1023/a:1015739130208

PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade

Atıf İçin Kopyala

KAYASELCUK F., ZORLUDEMIR S. , GUMURDULU D. , ZEREN H., Erman T.

JOURNAL OF NEURO-ONCOLOGY, cilt.57, ss.115-121, 2002 (SCI İndekslerine Giren Dergi)

Cilt numarası: 57 Konu: 2
Basım Tarihi: 2002
Doi Numarası: 10.1023/a:1015739130208
Dergi Adı: JOURNAL OF NEURO-ONCOLOGY
Sayfa Sayıları: ss.115-121

Özet

Determination of proteins in the control of proliferation in normal cells helps a better understanding of cellular transformation and proliferation mechanisms. Measurement of proliferative activity is important in determining the tumor grade, recurrence span and malignancy. Proliferating cell nuclear antigen (PCNA) and Ki-67 are two of the nuclear markers used to demonstrate the proliferative phase of the cell cycle.