Malignant Catarrhal Fever caused by Ovine Herpesvirus-2 in a cow

Avcı H., İpek E., Babaoğlu A. R. , Epikmen E. T. , Aydoğan A.

Etlik Veteriner Mikrobiyoloji Dergisi, cilt.31, ss.82-86, 2020 (Diğer Kurumların Hakemli Dergileri)

  • Cilt numarası: 31 Konu: 1
  • Basım Tarihi: 2020
  • Dergi Adı: Etlik Veteriner Mikrobiyoloji Dergisi
  • Sayfa Sayıları: ss.82-86


Malignant catarrhal fever (MCF) has been defined as a viral disease of domestic cattle and wild ruminants. We report a case of MCF caused by Ovine herpesvirus-2 (OvHV-2) in a 4-year-old female Holstein cow. Macroscopically, eyelids and conjunctiva were edematous and all superficial and, visceral lymph nodes were swollen. Microscopic examination showed that fibrinoid necrotic vasculitis in all tissues and organs; inflammatory changes in the vessel walls of the brain (pons, cerebrum and meninges); ulcerative changes in the oral mucosa; mild inflammatory cell infiltrations around the glomeruli and interstitium in the cortex of the kidney; widespread edema between the muscle bundles in the heart. PCR was performed to determine the presence of Ovine herpesvirus-2 nucleic acids and 386 bp product was obtained by primer sequences that replicated the pol gene region of OvHV-2. This PCR finding confirmed our diagnosis as sheep-associated MCF (SA-MCF).