Myeloid Antigen Positivity in Turkish Children With Acute Lymphoblastic Leukemia Lacks Influence on Prognosis


Tanyeli A., Erbey F., BAYRAM İ. , Komur M.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.11, no.6, pp.1823-1826, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 6
  • Publication Date: 2010
  • Title of Journal : ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Page Numbers: pp.1823-1826

Abstract

Introduction: Several studies have suggested that the presence of myeloid antigens is a poor prognostic factor in patients with acute lymphoid leukemia (ALL). Objective: We aimed to assess this possibility in Turkish patients. Materials and Methods: Seventy-three children with a diagnosis of ALL-L1 and 38 with ALL-L2 were included. Flow cytometry and fluorescein-isothiocynate conjugated antibodies were used to determined surface antigens on blasts. Results: Myeloid antigens were positive in 48.4% with ALL-L1 and 60.5% with ALL-L2, the difference not being significant. Overall survival rates of myeloid antigen positive patients at 36, 60, and 72 months were 76%, 58%, and 48%, respectively, comparable to the corresponding 70%, 56%, and 46% in myeloid antigen negative patients (p>0.05). Conclusion: We did not find any association between myeloid antigen positivity and clinical and laboratory features of ALL.