Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives


AKGÜL Ö., Ozturk I., Aygul A. , ERMERTCAN Ş.

MARMARA PHARMACEUTICAL JOURNAL, vol.21, no.2, pp.361-370, 2017 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.12991/marupj.300894
  • Title of Journal : MARMARA PHARMACEUTICAL JOURNAL
  • Page Numbers: pp.361-370

Abstract

In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity. The structures of the newly synthesized compounds 11-15 were evaluated by H-1 NMR, IR, MS-APCI and elemental analysis. Compounds (1-15) were tested against standard strains of Gram(+), Gram(-) bacteria and fungi by using disc diffusion and broth microdilution methods. Although disc diffusion method did not show any comparable results due to the solubility properties of the compounds; microdilution method results indicated that title compounds showed from poor to good activity against only Enterococcus faecalis. It can be concluded that phtalimido moiety, secondary aryl sulphonamide group and electron-donating group substitution on phenyl ring are essential for the antibacterial activity. Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2-phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin.