Effects of NSAIDs and hydroxyapatite coating on osseointegration: Biomechanical and histological study on rabbits
JOURNAL OF ORTHOPAEDIC SURGERY, cilt.25, sa.1, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.1177/2309499016684410
- Dergi Adı: JOURNAL OF ORTHOPAEDIC SURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Çukurova Üniversitesi Adresli: Evet
Özet
Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Methods: Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically. Results: HA-coated implants had a significantly better failure load and "percentage of bone-implant contact'' than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations. Conclusions: Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with grit-blasted implants.