Effects of NSAIDs and hydroxyapatite coating on osseointegration: Biomechanical and histological study on rabbits

Creative Commons License

Salduz A., Dikici F., Kilicoglu O. I., Balci H. I., Akgul T., KÜRKÇÜ M., ...More

JOURNAL OF ORTHOPAEDIC SURGERY, vol.25, no.1, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1177/2309499016684410
  • Journal Name: JOURNAL OF ORTHOPAEDIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Çukurova University Affiliated: Yes

Abstract

Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Methods: Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically. Results: HA-coated implants had a significantly better failure load and "percentage of bone-implant contact'' than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations. Conclusions: Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with grit-blasted implants.