Tracing immature myelin in acute disseminated encephalomyelitis


Anlar B., Karli-Oguz K., Yurtyapan O. Y. , Senbil N., Herguener O., Altunbasak S. , ...More

TURKISH JOURNAL OF PEDIATRICS, vol.48, no.3, pp.197-201, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2006
  • Title of Journal : TURKISH JOURNAL OF PEDIATRICS
  • Page Numbers: pp.197-201

Abstract

Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system.