Chronic inflammatory demyelinating neuropathy is an uncommon acquired poly neuropathy in children. Oral prednisolone, intravenous methyl prednisolone, and intravenous immunoglobulin are its main initial therapies. In patients resistant to these modalities, other immunosuppressants can be used. We demonstrate the efficacy of cyclosporin in three children with chronic inflammatory demyelinating neuropathy. Two of them were infants. None had adverse effects, except for hirsutism. We conclude that cyclosporin-treatment can be effective and safe in chronic inflammatory demyelinating neuropathy, when standard treatments are ineffective. Cyclosporin can also be used safely in infants. (C) 2009 by Elsevier Inc. All rights reserved.