Paal-Knorr Pyrrole Synthesis in Water


AKBAŞLAR D. , DEMİRKOL O. , Giray S.

SYNTHETIC COMMUNICATIONS, vol.44, no.9, pp.1323-1332, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 9
  • Publication Date: 2014
  • Doi Number: 10.1080/00397911.2013.857691
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.1323-1332

Abstract

Water was a suitable medium for Paal-Knorr pyrrole cyclocondensation. Hexa-2,5-dione was reacted with several aliphatic and aromatic primary amines, affording N-substituted 2,5-dimethyl pyrrole derivatives in good to excellent yields. An efficient, green method using water either as environmentally friendly solvent or catalyst was presented.