FRESENIUS ENVIRONMENTAL BULLETIN, vol.31, no.052022, pp.4775-4781, 2022 (SCI-Expanded)
Klebsiella pneumoniae causes infections espe-cially in hospital environment. Emergence of antibi-otics resistance among K. pneumoniae is a global concern. Resistance through Carbapenemase pro-duction reported in K. pneumoniae. The purpose of the study is to find the frequency of K. pneumoniae, related antibiogram, and phenotypic and molecular detection of carbapenemases. A total of 5475 sam-ples were processed for culture, in which 1140 ex-hibited bacterial growth. Among 1140 culture posi-tive samples, 110 isolates were K. pneumoniae. Phe-notypic and molecular methods were used for detec-tion of carbapenemases. All the isolates were re-sistant to Fosfomycin, cefotaxime, gentamicin and cloxacillin. 65.4% (n=72) isolates were resistant to meropenem and 57.2% (n=63) to imipenem. blaNDM gene was most prevalent (22.7%) followed by blaKPC (13.6%); however, blaOXA-48 was de-tected in one isolate. In the undertaken study, antibi-otic resistance was increasingly observed in K. pneu-moniae through carbapenemases. The current work will help to devise an appropriate antibiotic hospital policy to reduce K. pneumoniae resistance burden.