blaKPC, blaNDM AND blaOXA-48 Carbapenemases AMONG Klebsiella pneumoniae IN HOSPITALIZED PATIENTS: FIRST REPORT FROM NORTHWEST PAKISTAN

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Khaliq A., Rahman H., Khaliq H., Khan Z., Khan T. A., Khan R. S., ...Daha Fazla

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.31, sa.052022, ss.4775-4781, 2022 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 052022
  • Basım Tarihi: 2022
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.4775-4781
  • Çukurova Üniversitesi Adresli: Evet

Özet

Klebsiella pneumoniae causes infections espe-cially in hospital environment. Emergence of antibi-otics resistance among K. pneumoniae is a global concern. Resistance through Carbapenemase pro-duction reported in K. pneumoniae. The purpose of the study is to find the frequency of K. pneumoniae, related antibiogram, and phenotypic and molecular detection of carbapenemases. A total of 5475 sam-ples were processed for culture, in which 1140 ex-hibited bacterial growth. Among 1140 culture posi-tive samples, 110 isolates were K. pneumoniae. Phe-notypic and molecular methods were used for detec-tion of carbapenemases. All the isolates were re-sistant to Fosfomycin, cefotaxime, gentamicin and cloxacillin. 65.4% (n=72) isolates were resistant to meropenem and 57.2% (n=63) to imipenem. blaNDM gene was most prevalent (22.7%) followed by blaKPC (13.6%); however, blaOXA-48 was de-tected in one isolate. In the undertaken study, antibi-otic resistance was increasingly observed in K. pneu-moniae through carbapenemases. The current work will help to devise an appropriate antibiotic hospital policy to reduce K. pneumoniae resistance burden.