ObjectivesThe aim of this study was to compare the postoperative pain after root canal treatment using a carrier-based obturation system and two different sealers.Materials and methodsIn this prospective randomized clinical trial, 160 patients were selected. Patients with vital and devital teeth were randomized into four groups using a randomized block design with block sizes of 10 patients each. The groups were devital/vital teeth treated with iRoot SP sealer and devital/vital teeth treated with AH Plus sealer. Patients were prescribed ibuprofen, a 200-mg analgesic, if needed, and postoperative pain was recorded by visual analogue scale at 6, 12, 24, and 72h after obturation. Pain score and frequency of tablet intake were recorded and statistically analyzed.ResultsResults showed that there was no significant difference between groups in the incidence of postoperative pain; however, iRoot SP sealer was associated with less analgesic intake compared to AH Plus sealer.ConclusionThe use of different sealers did not significantly affect pain levels.Clinical relevanceiRoot SP sealer was associated with less analgesic intake compared to AH Plus sealer.