Macedonian Veterinary Review, cilt.43, ss.1-4, 2020 (Hakemli Üniversite Dergisi)
A one-day-old female Holstein calf was presented with subcutaneous masses spread over the whole body. Macroscopically,
the masses were firm in touch, greyish-white in colour, 0.5-2 cm in diameter range. Histopathological examination
confirmed the cutaneous Kaposiform hemangioendothelioma (KHE). Microscopic examination of the tumor revealed sheets
of spindled endothelial cells forming vascular slits. Immunohistochemically, the tumor cells and capillaries gave strongly
positive reaction for CD31 while vimentin, alpha smooth muscle actin and cytokeratin AE1/AE3 were negative. In this case,
macroscopical, detailed histhopathological and immunohistochemical findings of congenital KHE reported firstly in a newborn calf.