The protective effects of alpha lipoic acid on methotrexate induced testis injury in rats

Pinar N., Cakirca G., Ozgur T., Kaplan M.

BIOMEDICINE & PHARMACOTHERAPY, vol.97, pp.1486-1492, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 97
  • Publication Date: 2018
  • Doi Number: 10.1016/j.biopha.2017.11.078
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1486-1492
  • Keywords: Methotrexate, Testis injury, Alpha lipoic acid, TOXICITY, DAMAGE, LIVER
  • Çukurova University Affiliated: Yes


Methotrexate (MTX) is frequently used in the treatment of several diseases including cancers, rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and dermatomyositis. Previously, chemotherapeutic agents have been reported to cause permanent azoospermia and infertility in men. Methotrexate has been also shown to damage the seminiferous tubules of the testicles, lower the sperm count, and cause genetic mutations (in DNA) in sperm. In this study, we aimed to investigate the protective effects of alpha lipoic acid (ALA) on MTX-induced testicle damage in a rat model.