Novel Copper Bearing Schiff Bases with Photodynamic Anti-Inflammatory and Anti-Microbial Activities

AYAZ F., Gonul I., Demirbag B., Ocakoglu K.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, cilt.191, ss.716-727, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 191 Konu: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s12010-019-03223-7
  • Sayfa Sayıları: ss.716-727


Schiff bases and their copper complexes have been previously studied for their anti-inflammatory, anti-tumor as well as anti-microbial activities. Schiff bases can be derivatized to gain photoluminiscence capacity. This property of the schiff bases enables the transfer of the electrons upon absorption of the light at a specific wavelength. In this study, we exploited this attribute of novel copper bearing schiff bases and tested their photodynamic biological activities. These compounds exerted photodynamic anti-inflammatory activities on the in vitro activated mammalian macrophages. Compared with salicylic acid control groups, these novel schiff bases had stronger activity which became more prominent with photo-induction. Moreover, they also had anti-microbial activity on gram negative bacteria E.coli and gram positive bacteria S.aureus.This anti-microbial activity was stronger than that of Neomycin on both bacterial strains. Our results suggest their potential use as anti-inflammatory and anti-microbial agents both in the dark as well as after photo-induction.