NDM-1-producing Acinetobacter baumannii ST85 now in Turkey, including one isolate from a Syrian refugee

Heydari F., Mammina C., KÖKSAL F.

JOURNAL OF MEDICAL MICROBIOLOGY, vol.64, pp.1027-1029, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2015
  • Doi Number: 10.1099/jmm.0.000132
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1027-1029
  • Çukurova University Affiliated: Yes


New Delhi metallo-beta-lactamase-1 (NDM-1), an acquired class B carbapenennase, is a significant clinical threat owing to the extended hydrolysis of beta-lactams including carbapenems. Here, to the best of our knowledge we describe for the first time in Turkey two NDM-1-producing Acinetobacter baumannii isolates recovered from intensive care unit patients. The presence of bla(NDM-1) was detected by PCR and confirmed by sequencing. The clonal relationship was assessed by PFGE and multilocus sequence typing. Both isolates were positive for bla(NDM-1) and were attributed with the sequence type 85. One isolate was from a Syrian refugee, whereas the second was from a patient who had never travelled outside Turkey. Our findings confirmed that the rapid spread of NDM-1-producing Gram-negative organisms could become a major challenge for the treatment and control of healthcare-associated infections in our geographical area. They suggest also that NDM-1-producing strains and/or their genetic determinants are probably being imported from Syria to neighbouring countries.