Akademik Veri Yönetim Sistemi
JOURNAL OF ESSENTIAL OIL-BEARING PLANTS, cilt.28, sa.4, ss.1-20, 2025 (SCI-Expanded)
The increasing consumer preference for natural and organic products, coupledwith growing concerns over the side effects and resistance associated withsynthetic chemicals, has significantly increased the demand for essential oilsfor their potential pharmacological applications. However, many species remainunexplored.This study presents the first comprehensive analysis of Micromeriaaybalae essential oil, including its phytochemical composition, antioxidant andenzyme inhibitory activities, and molecular docking results. The essential oil,obtained by hydrodistillation of aerial parts, exhibited a 0.10% (v/w) yield,relatively low among Micromeria species. The essential oil of M. aybalae wasanalyzed by GC-MS, identifying 91.6% of its constituents. Major compoundsincluded caryophyllene oxide (38.5%), β-caryophyllene (6.5%), and α-pinene(6.3%). Antioxidant activity was moderate, with IC50 values of 11.56 mg/mL(DPPH) and 5.09 mg/mL (ABTS), compared to trolox (IC50 = 0.22 and 0.32mg/mL). Metal chelating activity was weak (IC50 = 1.86 mg/mL vs. EDTA at0.09 mg/mL). The oil showed moderate reducing power (EC50 = 4.38 mg/mL forCUPRAC, 3.95 mg/mL for FRAP), while trolox had stronger activity. Enzymeinhibition was observed for tyrosinase (IC50 = 1.59 mg/mL) and α-amylase (IC50= 12.74 mg/mL), though less potent than standards kojic acid and acarbose.In silico docking revealed that major constituents, especially caryophylleneoxide, interacted with α-amylase and tyrosinase active sites through hydrogenbonding (e.g., Asp197) and hydrophobic interactions (e.g., His61). This studypresents the first detailed analysis of M. aybalae essential oil, demonstratingits moderate bioactivity and suggesting potential for further investigation of itsactive compounds and synergistic effects.