Expression of Nectin-4 in Canine Mammary Carcinomas

Dolu H., Aydogan A.

ISRAEL JOURNAL OF VETERINARY MEDICINE, cilt.73, sa.3, ss.3-7, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 3
  • Basım Tarihi: 2018
  • Dergi Adı: ISRAEL JOURNAL OF VETERINARY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3-7
  • Çukurova Üniversitesi Adresli: Evet

Özet

In this research, 30 canine mammary tumor tissues which were diagnosed as tubulopapillary carcinoma and complex carcinoma were used. The routine avidin-biotin-peroxidase complex method (ABC) was applied for detection of Nectin-4, Proliferating Cell Nuclear Antigen (PCNA) and Ki-67 in these tissues. The results were analyzed comparatively and evaluated semi-quantitatively. Immunohistochemically, Nectin-4 was expressed in the plasma membrane and cytoplasm of malignant tumor cells. Statistically, positive, linear and a high correlation was observed between Nectin-4, PCNA and Ki-67 expressions. For this reason, it has been concluded that Nectin-4 may be of significant prognostic value relating to malignancy in canine mammary carcinomas.