Efficacy of gemcitabine in heavily pretreated advanced ovarian cancer patients


Bilgin T., Ozalp S., Yalcin O., Zorlu G., Vardar M., Ozerkan K.

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, vol.24, no.2, pp.169-170, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2003
  • Title of Journal : EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
  • Page Numbers: pp.169-170

Abstract

Single agent gemcitabine was used in recurrent epithelial ovarian cancer patients after standard treatment with debulking surgery and platin-paclitaxel based chemotherapy. Response rates and toxicity results were evaluated retrospectively. Gemcitabine was given in 1000 mg/m(2) intravenous infusion over 30 minutes at 1, 8, 15 days of every 28 days. Clinical response was evaluated with clinical findings, serum CA 125 levels, and computerized tomography. Twenty-two patients - ten as second-line, 11 as third-line, and one as fourth line - received gemcitabine. Seven patients received six courses, nine cases three, five cases two and one case one course of treatment. There were four (18.2%) partial and two (9.1%) complete responses with an overall response rate of 27.3%. Stable disease was also observed in three more cases. The progression-free interval was found to be a median of three months. Grade 3-4 neutropenia was seen in two (9.1%) and grade 3-4 thrombocytopenia was seen in four (18.2%) cases. Pancytopenia was observed in one (4.5%) patient. There was no grade 3-4 non-hematological toxicity.