Design and synthesis of novel 1,4-benzodiazepine surrogates as potential CCKA and CCKB antagonists via palladium-catalyzed three-component cascade reactions

DÖNDAŞ, HACI; Belveren, Samet; Poyraz, SAMET; Grigg, Ronald; Kilner, Colin; Ferrandiz-Saperas, Marcos; Selva, Elisabet; Sansano, Jose

doi:10.1016/j.tet.2017.11.017

Design and synthesis of novel 1,4-benzodiazepine surrogates as potential CCKA and CCKB antagonists via palladium-catalyzed three-component cascade reactions

DÖNDAŞ H. A., Belveren S., Poyraz S., Grigg R., Kilner C., Ferrandiz-Saperas M., ...Daha Fazla

TETRAHEDRON, cilt.74, sa.1, ss.6-11, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 74 Sayı: 1
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.tet.2017.11.017
Dergi Adı: TETRAHEDRON
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.6-11
Anahtar Kelimeler: Benzodiazepines, Cholecystokinin (CCK) receptor, Palladium, Allenylation, Carbonylation, CYCLIZATION-ANION CAPTURE, SITU GENERATED VINYLSTANNANES, EMPLOYING CARBON-MONOXIDE, MULTICOMPONENT REACTIONS, PRIVILEGED STRUCTURES, 5-COMPONENT CASCADES, OXYTOCIN ANTAGONIST, QUEUING-PROCESSES, B ANTAGONISTS, RELAY SWITCH
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Çukurova Üniversitesi Adresli: Hayır

Özet

Structurally diverse novel 1,4-benzodiazepine analogues related to selective CCKA antagonist MK-329, and CCKB antagonists L-365,260 and YM022 are prepared via palladium-catalyzed three component domino reactions involving allenylation-carbonylation-anion capture in one-pot cascade protocol in good to excellent yields. (C) 2017 Elsevier Ltd. All rights reserved.