Design and synthesis of novel 1,4-benzodiazepine surrogates as potential CCKA and CCKB antagonists via palladium-catalyzed three-component cascade reactions


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DÖNDAŞ H. A. , Belveren S., Poyraz S., Grigg R., Kilner C., Ferrandiz-Saperas M., ...Daha Fazla

TETRAHEDRON, cilt.74, sa.1, ss.6-11, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.tet.2017.11.017
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.6-11

Özet

Structurally diverse novel 1,4-benzodiazepine analogues related to selective CCKA antagonist MK-329, and CCKB antagonists L-365,260 and YM022 are prepared via palladium-catalyzed three component domino reactions involving allenylation-carbonylation-anion capture in one-pot cascade protocol in good to excellent yields. (C) 2017 Elsevier Ltd. All rights reserved.