Machine learning techniques have gained increasing demand in biomedical research due to capability of extracting complex relationships and correlations among members of the large data sets. Thus, over the past few decades, scientists have been concerned about computer information technology to provide computational learning methods for solving the complex medical problems. Support Vector Machine is an efficient classifier that is widely applied to biomedical and other disciplines. In recent years, new opportunities have been developed on improving Support Vector Machines' classification efficiency by combining with any other statistical and computational methods. This study proposes a new method of Support Vector Machines for influential classification using combined kernel functions. The classification performance of the developed method, which is a type of non-linear classifier, was compared to the standart Support Vector Machine method by applying on seven different datasets of medical diseases. The results show that the new method provides a significant improvement in terms of the probability excess.