Effects of Copper Oxide Nanoparticles on Tissue Accumulation and Antioxidant Enzymes of Galleria mellonella L.

Tuncsoy B. S., Tuncsoy M., Gomes T., Sousa V., Teixeira M. R., Bebianno M. J., ...Daha Fazla

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, cilt.102, sa.3, ss.341-346, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 102 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s00128-018-2529-8
  • Dergi Adı: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.341-346
  • Anahtar Kelimeler: Acetylcholinesterase, Antioxidant enzymes, Copper oxide nanoparticles, Galleria mellonella, Glutathione-s-transferase, GLUTATHIONE-S-TRANSFERASE, ENGINEERED NANOPARTICLES, SILVER NANOPARTICLES, ZNO NANOMATERIALS, OXIDATIVE STRESS, DAPHNIA-MAGNA, EXPOSURE, MUSSEL, TOXICITY, BIOMARKERS
  • Çukurova Üniversitesi Adresli: Evet

Özet

Effects of copper oxide nanoparticles (CuO NPs) were investigated in the midgut and fat body of Galleria mellonella. Fourth instar larvae were exposed to 10 mu g Cu/L of CuO until becoming last instar larvae, and catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) and acetylcholinesterase (AChE) and metal accumulation were evaluated. Copper accumulation was observed in midgut and fat body tissues of G. mellonella larvae exposed to CuO NPs. CuO NPs increased CAT activities in midgut and fat body, while SOD activities were decreased. CuO NPs exhibited significant increases in GST activity in fat body, while no significant differences were observed in the midgut of G. mellonella larvae. AChE activity significantly decreased in the midgut of G. mellonella whereas there is no significant effect on fat body in CuO NPs exposed larvae. In overall, these findings demonstrate that tissue accumulation and oxidative stress that is countered by antioxidant enzymes occur when G. mellonella larvae exposed to environmental concentration of CuO nanoparticles.