TETRAHEDRON, cilt.74, sa.27, ss.3564-3577, 2018 (SCI-Expanded)
Spiro-oxindoles, epi-Spirotryprostatin A and its analogues were prepared from a tactical combination of cascade catalytic bimetallic Pd (0)/Ag(I), intramolecular Heck and subsequent imine -> azomethine ylide -> 1,3-Dipolar cycloaddition reactions. The cascade features in situ generation of azomethine ylides and dipolarophiles and produces two new rings together with three stereocentres in good to excellent yields. (C) 2018 Elsevier Ltd. All rights reserved.