‘Clip-Cycle’ approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines

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Duff L. C., Yilmaz S., Agora A., Maddocks C. J., Fairlamb I. J. S., Unsworth W. P., ...Daha Fazla

Organic and Biomolecular Chemistry, cilt.24, sa.3, ss.608-612, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1039/d5ob01746g
  • Dergi Adı: Organic and Biomolecular Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, MEDLINE
  • Sayfa Sayıları: ss.608-612
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Çukurova Üniversitesi Adresli: Hayır

Özet

The ‘Clip-Cycle’ approach is a versatile and modular synthetic method for the synthesis of aza-heterocycles via sequential cross metathesis and aza-Michael reactions. In this manuscript, a series of innovations to the ‘Clip-Cycle’ approach are reported. First, the asymmetric ‘Clip-Cycle’ syntheses of 2,5- and 3,5-pyrrolidines from chiral starting materials are reported for the first time, using a kinetic resolution method. A two-directional ‘Clip-Cycle’ approach for the synthesis of pyrrolizidines and indolizidines is then introduced.