Manic Attack Possibly Triggered by Sulbutiamine: Case Report

Bulut M., Virit O., Selek S., Savas E., Bulbul F. , Dalkilic A., ...Daha Fazla

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.31, sa.2, ss.487-489, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 31 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5336/medsci.2009-13352
  • Sayfa Sayıları: ss.487-489


Sulbutiamine is a precursor of thiamine that crosses the blood-brain barrier. The modulatory effects on both dopaminergic and glutamatergic transmissions within the prefrontal cortex could play a pivotal role in the therapeutic action of sulbutiamine. Sulbutiamine is currently used for the treatment of fatigue, exhaustion and asthenia in physical and psychiatric disorders; however, it does not have any psycho-stimulant properties. While sulbutiamine has no anti-depressive effect, it exhibits several psychotropic effects such as a decrease in psycho-behavioural inhibition occurring in major depressive disorder. In this report, we describe a possible case of sulbutiamine-triggered manic attack in a patient with major depressive disorder, who later developed bipolar I disorder with spontaneous manic episodes. To our knowledge, this is the first possible case of sulbutiamine-triggered manic attack at the proper therapeutic dosage of sulbutiamine in a major depressive patient.