Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma

KARABULUT M., GUNALDI M., ALIS H., Afsar C. U., Karabulut S., SERİLMEZ M., ...More

CLINICAL & TRANSLATIONAL ONCOLOGY, vol.18, no.2, pp.160-171, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s12094-015-1348-1
  • Journal Name: CLINICAL & TRANSLATIONAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.160-171
  • Çukurova University Affiliated: No

Abstract

Nectins are a family of integral protein and immunoglobulin-like cell adhesion molecules involved in the formation of functioning adherence and tight junctions. Aberrant expression is associated with cancer progression, apoptosis and cell proliferation but little is known how these effects change in cell behavior. The objective of this study was to evaluate the serum levels of nectin-2 with regard to diagnostic, predictive and prognostic value in colorectal cancer (CRC) patients.