The Neogene Adana Basin of SE Turkey was initiated after thrust emplacement of the Tauride Belt to the north of the basin. Seismic reflection profiles across the southern part of the Adana Basin provide information on structural and stratigraphic evolution of the basin. Based on seismic character and the identification of unconformities, three megasequences and two mega sequence boundaries are identified. The first megasequence is partly coincident with an early Miocene rifting event and it comprises reefs that have grown on fault footwall crests with fore and back-reef sediments in intervening lows. Subsequent rapid flexurally induced subsidence generated an under-filled basin which was then passively filled by turbiditic sediments (megasequence 2) showing aggradational character on seismic profiles. Further extensional faulting and coupled sinistral wrench faulting took place after the deposition of megasequence 2. Erosional truncation of its upper part is followed by the deposition of continental and shallow marine sediments of megasequence 3 which shows localized progradational sequences characteristic of shallow water deposition. Further minor extensional faulting took place after the deposition of megasequence 3.