Effect of colchicine on cyclosporine nephrotoxicity, reduction of TGF-beta overexpression, apoptosis, and oxidative damage: An experimental animal study


DISEL U., Paydas S. , DOGAN A., GULFILIZ G., YAVUZ S.

TRANSPLANTATION PROCEEDINGS, cilt.36, ss.1372-1376, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background. Proinflamatory and profibrotic cytokines may be responsible for the cyclosporine A nephrotoxicity. Increased levels of apoptosis, free oxygen redicals, and transforming growth factor beta (TGF-beta), may play an important roles in the pathogenesis of nephrotoxicity. In this experimental animal study, we sought to investigate the effects of colchicine on the cyclosporine nephrotoxicity.