Effect of colchicine on cyclosporine nephrotoxicity, reduction of TGF-beta overexpression, apoptosis, and oxidative damage: An experimental animal study


DISEL U., Paydas S. , DOGAN A., GULFILIZ G., YAVUZ S.

TRANSPLANTATION PROCEEDINGS, cilt.36, sa.5, ss.1372-1376, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Konu: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.transproceed.2004.05.078
  • Dergi Adı: TRANSPLANTATION PROCEEDINGS
  • Sayfa Sayıları: ss.1372-1376

Özet

Background. Proinflamatory and profibrotic cytokines may be responsible for the cyclosporine A nephrotoxicity. Increased levels of apoptosis, free oxygen redicals, and transforming growth factor beta (TGF-beta), may play an important roles in the pathogenesis of nephrotoxicity. In this experimental animal study, we sought to investigate the effects of colchicine on the cyclosporine nephrotoxicity.