Akademik Veri Yönetim Sistemi
Acta Pharmaceutica Sciencia, cilt.62, sa.4, ss.839-858, 2024 (Scopus)
A North African endemic plant known as Warionia saharae Benth. & Coss is frequently used in Morocco for treating digestive problems. In this work, the possible in vivo antidiarrheal effect of the aqueous extract of aerial part of this plant was evaluated to confirm its traditional use, also, the organic fractions were tested in vitro on antimicrobial activity. The results obtained from the in vivo study of the antidiarrheal activity of the aqueous extract showed significant inhibition against the diarrheal effect induced by castor oil with 75.07% at a 400 mg/kg dose. Additionally, this extract significantly inhibited the amount of fluid that accumulated in the intestinal lumen with 38.45% at 400 mg/kg, as well as the intestinal transit of activated charcoal. The antibacterial activities were tested for the aqueous extract and four organic fractions against five strains for the Gram-negative and the Gram-positive bacteria. Also, these extracts were tested for antifungal activity. The results of the study reveal that the aqueous extract and the dichloromethane fraction demonstrated the greatest levels of activity against the tested bacteria. This work provides a possible strategy for treating bacterial infections, which can be used to take advantage of this antimicrobial activities promising in the treatment of diarrhea caused primarily by these bacteria.