Investigation of the Usability of Kisspeptin and Oxidative Stress Parameters in the Early Diagnosis of Asymptomatic Cystic Endometrial Hyperplasia in Dogs.

Kurt S., Eski F., Mis L.

Reproduction in domestic animals = Zuchthygiene, cilt.56, ss.1529-1535, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/rda.14016
  • Dergi Adı: Reproduction in domestic animals = Zuchthygiene
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1529-1535
  • Anahtar Kelimeler: cystic endometrial hyperplasia, dog, kisspeptin, oxidative stress, PYOMETRA COMPLEX, CANINE PYOMETRA, RECEPTOR, EXPRESSION, PREGNANCY, BITCHES, PATHOGENESIS, TROPHOBLAST, MUCOMETRA, ESTROGEN
  • Çukurova Üniversitesi Adresli: Evet

Özet

This study aimed to investigate the differences in oxidative stress index (OSI) and kisspeptin levels in clinically asymptomatic dogs with cystic endometrial hyperplasia (CEH) compared to healthy and pregnant dogs, and to determine the usability of the obtained results in the diagnosis of asymptomatic CEH. The study comprised three groups; a healthy (n = 8), a pregnant (n = 10) and a CEH (n = 10). All dogs in the three groups were included in the study at the 30 +/- 3th day after estrus, and blood samples were collected for analysis of kisspeptin, total antioxidant status (TAS), total oxidant status (TOS), progesterone (P4), estradiol (E2) and some biochemical parameters (TSH; thyroid stimulating hormone, ALT; alanine aminotransferase, AST; aspartate aminotransferase, ALP; alkaline phosphatase, LDH; lactate dehydrogenase, CRE; creatine and BUN; blood urea nitrogen). In addition, OSI value was calculated. P4 and ALT and BUN levels were significantly lower and higher in CEH group than the pregnant group, respectively (p < .05). While kisspeptin and TAS levels were significantly lower in CEH group compared to the healthy and pregnant groups (p < .01), OSI level increased dramatically. In conclusion, it was confirmed that CEH clearly affected kisspeptin and OSI levels, and it is thought that these parameters may be an alternative diagnostic tool for the detection of CEH after further studies.