Akademik Veri Yönetim Sistemi
ESMO OPEN, cilt.10, sa.3, ss.20-21, 2025 (SCI-Expanded, Scopus)
Background: Desmoid tumors are aggressive tumors with unknown metastasis and
differentiation rates. Desmoid tumors with hereditary syndromes can develop in 5-
15% of patients with FAP syndrome. CD 47, also known as Integrin-associated protein,
CD47 has an important role in many biological processes such as immune cell activation,
cell migration and neural development. In this study, we aimed to evaluate the
correlation of CD47 expression with prognostic parameters in desmoid tumor cases.
Thus, we wanted to evaluate whether anti-CD 47 drugs, which have been studied
recently, can be used in desmoid tumors in the future.
Methods: Patients over the age of 18 who were histopathologically diagnosed with
desmoid tumor were included in the study. Demographic data of the patients,
treatments they received, tumor location, genetic tests if there was a concomitant
hereditary syndrome, and CD 47 expression in pathology preparations were evaluated.
In the immunohistochemical evaluation of CD47 expression; preparations were
evaluated in terms of the extent of expression in tumor cells and the intensity of
expression (low, moderate, high expression). Expression characteristics were evaluated
with demographic characteristics of the patients, accompanying hereditary
syndromes such as FAP, recurrence rates, and surgical responses.
Results: 128 patients diagnosed with desmoid tumor were included in the study. Only
9 of the 128 patients were diagnosed with hereditary familial polyposis syndrome,
while the other 121 patients were diagnosed with sporadic desmoid tumor. When the
CD 47 staining characteristics of our patients were evaluated as IHC in pathology
preparations, only 11 out of 128 patients showed staining characteristics. The staining
characteristics were slightly intense in all 11 patients. No significant relationship was
found between the staining characteristics and being a sporadic or hereditary disease.
None of our patients with a diagnosis of FAP showed CD 47 staining characteristics.
Again, no relationship was found between the number of recurrences and the CD 47
staining characteristics.
Conclusions: In our study, we could not detect CD 47 staining feature in both sporadic
desmoid tumors and FAP-related desmoid tumors.