CHEK2 1100delC, IVS2+1G > A and I157T mutations are not present in colorectal cancer cases from Turkish population


BAYRAM S., TOPAKTAŞ M. , AKKIZ H. , Bekar A., Akgollu E.

CANCER EPIDEMIOLOGY, cilt.36, ss.453-457, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 36 Konu: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.canep.2012.03.008
  • Dergi Adı: CANCER EPIDEMIOLOGY
  • Sayfa Sayıları: ss.453-457

Özet

Background: The cell cycle checkpoint kinase 2 (CHEK2) protein participates in the DNA damage response in many cell types. Germline mutations in CHEK2 (1100delC, IVS2+1G>A and I157T) have been impaired serine/threonine kinase activity and associated with a range of cancer types. This hospital-based case-control study aimed to investigate whether CHEK2 1100delC, IVS2+1G>A and I157T mutations play an important role in the development of colorectal cancer (CRC) in Turkish population.