CHEK2 1100delC, IVS2+1G > A and I157T mutations are not present in colorectal cancer cases from Turkish population
CANCER EPIDEMIOLOGY, cilt.36, sa.5, ss.453-457, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 5
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.canep.2012.03.008
- Dergi Adı: CANCER EPIDEMIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.453-457
- Çukurova Üniversitesi Adresli: Evet
Özet
Background: The cell cycle checkpoint kinase 2 (CHEK2) protein participates in the DNA damage response in many cell types. Germline mutations in CHEK2 (1100delC, IVS2+1G>A and I157T) have been impaired serine/threonine kinase activity and associated with a range of cancer types. This hospital-based case-control study aimed to investigate whether CHEK2 1100delC, IVS2+1G>A and I157T mutations play an important role in the development of colorectal cancer (CRC) in Turkish population.