Response of antioxidant system of freshwater fish Oreochromis niloticus to acute and chronic metal (Cd, Cu, Cr, Zn, Fe) exposures


Atli G., CANLI M.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, vol.73, no.8, pp.1884-1889, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 8
  • Publication Date: 2010
  • Doi Number: 10.1016/j.ecoenv.2010.09.005
  • Journal Name: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1884-1889
  • Keywords: Antioxidant enzymes, CAT, SOD, GPX, GST, GR, Metal, Fish Oreochromis niloticus, INDUCED OXIDATIVE STRESS, SUPEROXIDE-DISMUTASE, SCENEDESMUS-OBLIQUUS, BIOCHEMICAL-CHANGES, CADMIUM EXPOSURE, COPPER, TILAPIA, GLUTATHIONE, BIOMARKERS, CATALASE
  • Çukurova University Affiliated: Yes

Abstract

Antioxidant systems are known to be sensitive to metal exposures and are suggested to use in predicting sublethal metal toxicity. In this study, several antioxidant enzymes, such as catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GR) were measured in the liver and kidney of Oreochromis niloticus exposed to sublethal concentrations of metals (Cd, Cu, Cr, Zn and Fe), using an acute (20 mu M, 48 h) or subchronic (10 mu M, 20 d) protocol. Beside the several increases of antioxidant enzyme activities, general inhibition was recorded after acute and chronic metal exposures. Results indicated that there were variations in responses of the enzymes to metal exposures, depending upon tissues, metals and exposure types. This study emphasized that the antioxidant enzymes are very sensitive to metals as their activities altered significantly, suggesting they could be helpful in predicting sublethal metal toxicity and useful as an early warning tool in natural monitoring studies. (c) 2010 Elsevier Inc. All rights reserved.