The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide


Besen A., Kose F., Paydaş S. , Gönlüşen G. , Inal T., Doğan A. , ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.41, pp.919-926, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41
  • Publication Date: 2009
  • Doi Number: 10.1007/s11255-008-9496-7
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.919-926
  • Keywords: Acute renal failure, COX expression, Diclofenac sodium, Furosemide, Rat kidney, EXPRESSION, INHIBITION, DIURETICS

Abstract

Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearance, and COX-1 and COX-2 expression in the renal cortex.