INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.41, pp.919-926, 2009 (Journal Indexed in SCI)
Article / Article
Title of Journal :
INTERNATIONAL UROLOGY AND NEPHROLOGY
Acute renal failure, COX expression, Diclofenac sodium, Furosemide, Rat kidney, EXPRESSION, INHIBITION, DIURETICS
Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearance, and COX-1 and COX-2 expression in the renal cortex.