The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide
INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.41, ss.919-926, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41
- Basım Tarihi: 2009
- Doi Numarası: 10.1007/s11255-008-9496-7
- Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.919-926
- Anahtar Kelimeler: Acute renal failure, COX expression, Diclofenac sodium, Furosemide, Rat kidney, EXPRESSION, INHIBITION, DIURETICS
- Çukurova Üniversitesi Adresli: Evet
Özet
Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearance, and COX-1 and COX-2 expression in the renal cortex.