The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide


Besen A., Kose F., Paydaş S. , Gönlüşen G. , Inal T., Doğan A. , ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.41, ss.919-926, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s11255-008-9496-7
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Sayfa Sayıları: ss.919-926

Özet

Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearance, and COX-1 and COX-2 expression in the renal cortex.