The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide

Besen A., Kose F., Paydaş S., Gönlüşen G., Inal T., Doğan A., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.41, ss.919-926, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s11255-008-9496-7
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.919-926
  • Anahtar Kelimeler: Acute renal failure, COX expression, Diclofenac sodium, Furosemide, Rat kidney, EXPRESSION, INHIBITION, DIURETICS
  • Çukurova Üniversitesi Adresli: Evet

Özet

Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearance, and COX-1 and COX-2 expression in the renal cortex.