Impact of follicle-stimulating hormone receptor variants in female infertility

Ilgaz N. S., Aydos O. S. E., Karadag A., Taspinar M., ERYILMAZ O. G., Sunguroglu A.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol.32, no.11, pp.1659-1668, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 11
  • Publication Date: 2015
  • Doi Number: 10.1007/s10815-015-0572-5
  • Journal Name: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1659-1668
  • Keywords: Follicle-stimulating hormone receptor, Single nucleotide polymorphisms, Infertility, PREMATURE OVARIAN FAILURE, FSH-RECEPTOR, LUTEINIZING-HORMONE, GENE, WOMEN, POLYMORPHISMS, MUTATION, MEN, IDENTIFICATION, POPULATION
  • Çukurova University Affiliated: Yes

Abstract

Follicle-stimulating hormone (FSH) and its receptor play a major role in the development of follicles and regulation of steroidogenesis in the ovary and spermatogenesis in the testis. We aim to analyze the role of FSHR gene variants (single nucleotide polymorphisms (SNPs) in exon 10 (codon 307 and 680) and in the core promoter region (at position -29) and Ala189Val inactivating mutation) in Turkish infertile women. There were studies analyzing the effects of the SNPs in exon 10 (codon 307 and 680) and in the core promoter region (at position -29) of the FSHR gene on spermatogenesis, but to our knowledge, there were no studies analyzing the effects of these three SNP combinations on female fertility.