Impact of follicle-stimulating hormone receptor variants in female infertility


Ilgaz N. S. , Aydos O. S. E. , Karadag A., Taspinar M., ERYILMAZ O. G. , Sunguroglu A.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.32, ss.1659-1668, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 11
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10815-015-0572-5
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Sayfa Sayıları: ss.1659-1668

Özet

Follicle-stimulating hormone (FSH) and its receptor play a major role in the development of follicles and regulation of steroidogenesis in the ovary and spermatogenesis in the testis. We aim to analyze the role of FSHR gene variants (single nucleotide polymorphisms (SNPs) in exon 10 (codon 307 and 680) and in the core promoter region (at position -29) and Ala189Val inactivating mutation) in Turkish infertile women. There were studies analyzing the effects of the SNPs in exon 10 (codon 307 and 680) and in the core promoter region (at position -29) of the FSHR gene on spermatogenesis, but to our knowledge, there were no studies analyzing the effects of these three SNP combinations on female fertility.