Targeted treatment with pazopanib in metastatic soft tissue sarcoma: Nearly complete response in two cases


Sedef A. M. , Kose F., Dogan O., Ergun T., Sezer A., Mertsoylu H., ...Daha Fazla

MOLECULAR AND CLINICAL ONCOLOGY, cilt.3, ss.400-402, 2015 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 3 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3892/mco.2014.456
  • Dergi Adı: MOLECULAR AND CLINICAL ONCOLOGY
  • Sayfa Sayıları: ss.400-402

Özet

Soft tissue sarcomas (STS) are a group of rare mesenchymal cancers that include approximately 50 histological types and account for 1% of all adult cancers. The standard curative treatment option for localized disease is surgical resection and, if a surgically removed tumor exhibits high-risk characteristics, adjuvant chemotherapy and radiotherapy may be administered. Sarcoma presenting at an advanced stage has a dismal prognosis and survival has not markedly improved over the last 20 years. The standard first-line treatment for advanced STS, other than gastrointestinal stromal tumors, is cytotoxic chemotherapy. Therapies targeting pro-angiogenic factors have been a focus of drug development for STS over the last few years. Pazopanib, a multitargeted tyrosine kinase inhibitor, is a novel treatment option for patients with metastatic STS in the second-line setting. This is a presentation of 2 case reports of patients with metastatic STS who responded well to treatment with pazopanib.