Targeted treatment with pazopanib in metastatic soft tissue sarcoma: Nearly complete response in two cases


Sedef A. M. , Kose F., Dogan O., Ergun T., Sezer A., Mertsoylu H., ...More

MOLECULAR AND CLINICAL ONCOLOGY, vol.3, no.2, pp.400-402, 2015 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.3892/mco.2014.456
  • Title of Journal : MOLECULAR AND CLINICAL ONCOLOGY
  • Page Numbers: pp.400-402

Abstract

Soft tissue sarcomas (STS) are a group of rare mesenchymal cancers that include approximately 50 histological types and account for 1% of all adult cancers. The standard curative treatment option for localized disease is surgical resection and, if a surgically removed tumor exhibits high-risk characteristics, adjuvant chemotherapy and radiotherapy may be administered. Sarcoma presenting at an advanced stage has a dismal prognosis and survival has not markedly improved over the last 20 years. The standard first-line treatment for advanced STS, other than gastrointestinal stromal tumors, is cytotoxic chemotherapy. Therapies targeting pro-angiogenic factors have been a focus of drug development for STS over the last few years. Pazopanib, a multitargeted tyrosine kinase inhibitor, is a novel treatment option for patients with metastatic STS in the second-line setting. This is a presentation of 2 case reports of patients with metastatic STS who responded well to treatment with pazopanib.