Dissecting the Interplay Mechanism among Process Parameters toward the Biofabrication of High‐Quality Shapes in Embedded Bioprinting


Wu Y., Yang X., Gupta D., Alioglu M. A., Qin M., Özbolat V., ...Daha Fazla

ADVANCED FUNCTIONAL MATERIALS, sa.1, ss.2313088, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/adfm.202313088
  • Dergi Adı: ADVANCED FUNCTIONAL MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2313088
  • Çukurova Üniversitesi Adresli: Evet

Özet

AbstractEmbedded bioprinting overcomes the barriers associated with the conventional extrusion‐based bioprinting process as it enables the direct deposition of bioinks in 3D inside a support bath by providing in situ self‐support for deposited bioinks during bioprinting to prevent their collapse and deformation. Embedded bioprinting improves the shape quality of bioprinted constructs made up of soft materials and low‐viscosity bioinks, leading to a promising strategy for better anatomical mimicry of tissues or organs. Herein, the interplay mechanism among the printing process parameters toward improved shape quality is critically reviewed. The impact of material properties of the support bath and bioink, printing conditions, cross–linking mechanisms, and post‐printing treatment methods, on the printing fidelity, stability, and resolution of the structures is meticulously dissected and thoroughly discussed. Further, the potential scope and applications of this technology in the fields of bioprinting and regenerative medicine are presented. Finally, outstanding challenges and opportunities of embedded bioprinting as well as its promise for fabricating functional solid organs in the future are discussed.