RENAL TUBULAR ACIDOSIS AS A COMPLICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA

Bayram E.

3rd International Congress on Leukemia – Lymphoma – Myeloma, İstanbul, Türkiye, 11 - 14 Mayıs 2011, ss.240-241

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.240-241
  • Çukurova Üniversitesi Adresli: Hayır

Özet

RENAL TUBULAR ACIDOSIS AS A COMPLICATION OF

ACUTE LYMPHOBLASTIC LEUKEMIA

A 18-year-old girl was admitted to hematology ward

of Çukurova University Hospital with anemia and thrombocytopenia.

A bone marrow examination revealed precursor

B cell acute lymphoblastic leukemia. We have

observed persistent hypokalemia during hospitalisation

period without any other reason for hypokalemia. There

was a normal anion gap hyperchloremic metabolic acidosis.

Urinary and arterial blood gas analysis demonstrated

proximal renal tubular acidosis. A hyperfractionated

cyclophosphamide, vincristine, doxorubicin, and dexamethasone

(hyper-CVAD) regimen resulted in complete

remission. Interestingly metabolic acidosis also resolved

after institution of chemotherapy. Temporal relation

between hematologic recovery and resolution of metabolic

acidosis made us think that defect in proximal bicarbonate

reclamation in this case was most likely attributable

to leukemic infiltration of renal tubules.