The issue of nervous system, one of the subjects of biology, is difficult and abstract to understand, and is inherently capable of causing misconceptions. Conducting a class allocated to the subject matter by employing effective teaching methods and techniques is, therefore, very important for fully understanding the subject and for eliminating such conceptual mistakes. Information and communication technologies are frequently used in biology education in order to form effective learning environments. In this way, problems which cannot be resolved through traditional methods of teaching can be overcome. This research aims at determining the effects of teaching through simulation-which has been performed in relation to the topic of nerve conduction-on concept teaching and on eliminating the misconceptions. The study group for the research was composed of 25 third year students attending the Biology Education Department of Hacettepe University Faculty of Education. In consequence, it was observed that the misconceptions carried by the students were removed thanks to classes taught through the simulation. (C) 2015 Published by Elsevier Ltd.