Severe Pulmonary Toxicity Associated with Fludarabine and Possible Contribution of Rituximab

Disel U., PAYDAŞ S., Yavuz S., Karakoc E.

CHEMOTHERAPY, vol.56, no.2, pp.89-93, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1159/000305255
  • Journal Name: CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-93
  • Çukurova University Affiliated: Yes


Fludarabine is a nucleoside analogue used in the treatment of low-grade lymphoproliferative disorders and in conditioning regimens of non-myeloablative allogeneic stem cell transplantation. This is a relatively safe drug for clinical use but may cause side effects, some of which may be life-threatening. Here a case of severe pulmonary toxicity associated with fludarabine and a possible contribution of rituximab is presented and the literature reviewed. Copyright (C) 2010 S. Karger AG, Basel