Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

Schaefer, AYSUN; Trachtman, Howard; Wuhl, Elke; Kirchner, Marietta; Hayek, Salim; Anarat, ALİ; DÜZOVA, ALİ; Mir, Sevgi; Paripovic, Dusan; Yilmaz, Alev; Lugani, Francesca; Arbeiter, Klaus; Litwin, Mieczyslaw; Oh, Jun; Matteucci, Maria; Gellermann, Jutta; Wygoda, Simone; Jankauskiene, Augustina; Klaus, Gunter; Dusek, Jiri; Testa, Sara; Zurowska, Aleksandra; Afonso, Alberto; Tracy, Melissa; Wei, Changli; Sever, Sanja; Smoyer, William; Reiser, Jochen

doi:10.1001/jamapediatrics.2017.2914

Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children

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Schaefer F., Trachtman H., Wuhl E., Kirchner M., Hayek S. S., Anarat A., ...More

JAMA PEDIATRICS, vol.171, no.11, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 171 Issue: 11
Publication Date: 2017
Doi Number: 10.1001/jamapediatrics.2017.2914
Journal Name: JAMA PEDIATRICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Çukurova University Affiliated: Yes

Abstract

IMPORTANCE Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level and cystatin C-derived estimated glomerular filtration rate (eGFR) and assessment of proteinuria in spot or timed urine samples, are of limited value in identifying patients at risk of progressive kidney function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 in adults.