Clozapine induced enuresis treated with Amitriptyline: A case report


DEMİRKOL M. E. , Tamam L.

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, cilt.8, ss.234-236, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4328/jcam.5277
  • Dergi Adı: JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE
  • Sayfa Sayıları: ss.234-236

Özet

Tardive dyskinesia is characterized by involuntary movements which appear in connection with long-term blockage of dopamine 2 receptors following the use of antipsychotics. One of the treatment options in cases of tardive dyskinesia which occasionally induced by aripiprazole is clozapine. Clozapine is distinguished from other antipsychotics by its effective strength because of its unique receptor profile and its side effects. Clozapine may cause enuresis by various mechanisms. Among the pharmacological choices for the treatment of clozapine-related enuresis are desmopressin, oxybutynin, trihexyphenidyl, amitriptyline, aripiprazole, ephedrine, and verapamil. The patient's psychiatric diagnosis determines the choice of medication with their possible side effects.