Tardive dyskinesia is characterized by involuntary movements which appear in connection with long-term blockage of dopamine 2 receptors following the use of antipsychotics. One of the treatment options in cases of tardive dyskinesia which occasionally induced by aripiprazole is clozapine. Clozapine is distinguished from other antipsychotics by its effective strength because of its unique receptor profile and its side effects. Clozapine may cause enuresis by various mechanisms. Among the pharmacological choices for the treatment of clozapine-related enuresis are desmopressin, oxybutynin, trihexyphenidyl, amitriptyline, aripiprazole, ephedrine, and verapamil. The patient's psychiatric diagnosis determines the choice of medication with their possible side effects.